TY - JOUR
T1 - Functional imaging of spontaneous activity of the brain using green-autofluorescence of flavoprotein
AU - Katayama, Norihiro
AU - Nakagawa, Daiki
AU - Ueno, Ayako
AU - Karashima, Akihiro
AU - Nakao, Mitsuyuki
PY - 2014/8/17
Y1 - 2014/8/17
N2 - Since the response of the brain to a sensory input is dependent on the state of the brain that fluctuates spontaneously with time, it is very important to know the spontaneous activity of the brain for the stimulus-to-response property evaluation. Recently, green auto-fluorescence (GAF) emitted from mitochondrial flavoprotein has been proved to be correlated with the neuronal activity of the brain. The GAF imaging technique has been used for brain mapping. However, it has not been used for the spontaneous activity of the brain because its signal-to-noise ratio (S/N) is low. To improve S/N, we have optimized the fluorescent measurement system and introduced digital signal processing techniques. In this presentation, we will show that GAF of the brain has a component which is correlated with spontaneous electroencephalographic activity, and discuss utilization for the functional imaging of spontaneous brain activity.
AB - Since the response of the brain to a sensory input is dependent on the state of the brain that fluctuates spontaneously with time, it is very important to know the spontaneous activity of the brain for the stimulus-to-response property evaluation. Recently, green auto-fluorescence (GAF) emitted from mitochondrial flavoprotein has been proved to be correlated with the neuronal activity of the brain. The GAF imaging technique has been used for brain mapping. However, it has not been used for the spontaneous activity of the brain because its signal-to-noise ratio (S/N) is low. To improve S/N, we have optimized the fluorescent measurement system and introduced digital signal processing techniques. In this presentation, we will show that GAF of the brain has a component which is correlated with spontaneous electroencephalographic activity, and discuss utilization for the functional imaging of spontaneous brain activity.
KW - Biological engineering
KW - Medical engineering
KW - Paper format
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U2 - 10.11239/jsmbe.52.OS-69
DO - 10.11239/jsmbe.52.OS-69
M3 - Article
AN - SCOPUS:84939443591
VL - 52
SP - OS-69-OS-70
JO - BME = Bio medical engineering / henshu, Nihon ME Gakkai
JF - BME = Bio medical engineering / henshu, Nihon ME Gakkai
SN - 1347-443X
ER -