TY - JOUR
T1 - Functional expression on human trophoblasts of interleukin 4 and interleukin 7 receptor complexes with a common γ chain
AU - Saito, Shigeru
AU - Harada, Naoya
AU - Ishii, Naoto
AU - Morii, Takeshi
AU - Sakakura, Shigeyoshi
AU - Enomoto, Masahiro
AU - Umekage, Hideshi
AU - Nishikawa, Kiyoshi
AU - Narita, Nobuhiro
AU - Nakamura, Masataka
AU - Sugamura, Kazuo
AU - Morikawa, Hajime
PY - 1997/2/13
Y1 - 1997/2/13
N2 - The γ chain in the high-affinity receptor complex for interleukin 2(IL-2) is used in receptor complexes for IL-4 and IL-7. We examined expression and function of the γ chain in trophoblast cells. Flow cytometric studies demonstrated that the human placental cell line and choriocarcinoma cell lines expressed the IL-2R γ chain. None of these cell lines expressed the IL-2R α and β chains, whereas the α chains of IL-4R and IL-7R were present. The γ chain and IL-4R and IL-7R mRNA were detected in human placental trophoblasts by the in situ hybridization method. The release of human chorionic gonadotropin by trophoblasts was accelerated by IL-4 and IL-7 in a concentration-dependent manner. These findings indicate that IL-4 and IL-7 are involved in trophoblast function.
AB - The γ chain in the high-affinity receptor complex for interleukin 2(IL-2) is used in receptor complexes for IL-4 and IL-7. We examined expression and function of the γ chain in trophoblast cells. Flow cytometric studies demonstrated that the human placental cell line and choriocarcinoma cell lines expressed the IL-2R γ chain. None of these cell lines expressed the IL-2R α and β chains, whereas the α chains of IL-4R and IL-7R were present. The γ chain and IL-4R and IL-7R mRNA were detected in human placental trophoblasts by the in situ hybridization method. The release of human chorionic gonadotropin by trophoblasts was accelerated by IL-4 and IL-7 in a concentration-dependent manner. These findings indicate that IL-4 and IL-7 are involved in trophoblast function.
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U2 - 10.1006/bbrc.1997.6121
DO - 10.1006/bbrc.1997.6121
M3 - Article
C2 - 9070294
AN - SCOPUS:18344419038
VL - 231
SP - 429
EP - 434
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
SN - 0006-291X
IS - 2
ER -