Functional expression on human trophoblasts of interleukin 4 and interleukin 7 receptor complexes with a common γ chain

Shigeru Saito; Naoya Harada; Naoto Ishii; Takeshi Morii; Shigeyoshi Sakakura; Masahiro Enomoto; Hideshi Umekage; Kiyoshi Nishikawa; Nobuhiro Narita; Masataka Nakamura; Kazuo Sugamura; Hajime Morikawa

doi:10.1006/bbrc.1997.6121

Functional expression on human trophoblasts of interleukin 4 and interleukin 7 receptor complexes with a common γ chain

Shigeru Saito, Naoya Harada, Naoto Ishii, Takeshi Morii, Shigeyoshi Sakakura, Masahiro Enomoto, Hideshi Umekage, Kiyoshi Nishikawa, Nobuhiro Narita, Masataka Nakamura, Kazuo Sugamura, Hajime Morikawa

MED - Medical Sciences

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

The γ chain in the high-affinity receptor complex for interleukin 2(IL-2) is used in receptor complexes for IL-4 and IL-7. We examined expression and function of the γ chain in trophoblast cells. Flow cytometric studies demonstrated that the human placental cell line and choriocarcinoma cell lines expressed the IL-2R γ chain. None of these cell lines expressed the IL-2R α and β chains, whereas the α chains of IL-4R and IL-7R were present. The γ chain and IL-4R and IL-7R mRNA were detected in human placental trophoblasts by the in situ hybridization method. The release of human chorionic gonadotropin by trophoblasts was accelerated by IL-4 and IL-7 in a concentration-dependent manner. These findings indicate that IL-4 and IL-7 are involved in trophoblast function.

Original language	English
Pages (from-to)	429-434
Number of pages	6
Journal	Biochemical and biophysical research communications
Volume	231
Issue number	2
DOIs	https://doi.org/10.1006/bbrc.1997.6121
Publication status	Published - 1997 Feb 13

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1006/bbrc.1997.6121

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Saito, S., Harada, N., Ishii, N., Morii, T., Sakakura, S., Enomoto, M., Umekage, H., Nishikawa, K., Narita, N., Nakamura, M., Sugamura, K., & Morikawa, H. (1997). Functional expression on human trophoblasts of interleukin 4 and interleukin 7 receptor complexes with a common γ chain. Biochemical and biophysical research communications, 231(2), 429-434. https://doi.org/10.1006/bbrc.1997.6121

Functional expression on human trophoblasts of interleukin 4 and interleukin 7 receptor complexes with a common γ chain. / Saito, Shigeru; Harada, Naoya; Ishii, Naoto; Morii, Takeshi; Sakakura, Shigeyoshi; Enomoto, Masahiro; Umekage, Hideshi; Nishikawa, Kiyoshi; Narita, Nobuhiro; Nakamura, Masataka; Sugamura, Kazuo; Morikawa, Hajime.

In: Biochemical and biophysical research communications, Vol. 231, No. 2, 13.02.1997, p. 429-434.

Research output: Contribution to journal › Article › peer-review

Saito, S, Harada, N, Ishii, N, Morii, T, Sakakura, S, Enomoto, M, Umekage, H, Nishikawa, K, Narita, N, Nakamura, M, Sugamura, K & Morikawa, H 1997, 'Functional expression on human trophoblasts of interleukin 4 and interleukin 7 receptor complexes with a common γ chain', Biochemical and biophysical research communications, vol. 231, no. 2, pp. 429-434. https://doi.org/10.1006/bbrc.1997.6121

Saito, Shigeru ; Harada, Naoya ; Ishii, Naoto ; Morii, Takeshi ; Sakakura, Shigeyoshi ; Enomoto, Masahiro ; Umekage, Hideshi ; Nishikawa, Kiyoshi ; Narita, Nobuhiro ; Nakamura, Masataka ; Sugamura, Kazuo ; Morikawa, Hajime. / Functional expression on human trophoblasts of interleukin 4 and interleukin 7 receptor complexes with a common γ chain. In: Biochemical and biophysical research communications. 1997 ; Vol. 231, No. 2. pp. 429-434.

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abstract = "The γ chain in the high-affinity receptor complex for interleukin 2(IL-2) is used in receptor complexes for IL-4 and IL-7. We examined expression and function of the γ chain in trophoblast cells. Flow cytometric studies demonstrated that the human placental cell line and choriocarcinoma cell lines expressed the IL-2R γ chain. None of these cell lines expressed the IL-2R α and β chains, whereas the α chains of IL-4R and IL-7R were present. The γ chain and IL-4R and IL-7R mRNA were detected in human placental trophoblasts by the in situ hybridization method. The release of human chorionic gonadotropin by trophoblasts was accelerated by IL-4 and IL-7 in a concentration-dependent manner. These findings indicate that IL-4 and IL-7 are involved in trophoblast function.",

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Functional expression on human trophoblasts of interleukin 4 and interleukin 7 receptor complexes with a common γ chain

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