Functional crosstalk between cell-surface and intracellular channels mediated by junctophilins essential for neuronal functions

Sho Kakizawa, Shigeki Moriguchi, Atsushi Ikeda, Masamitsu Iino, Hiroshi Takeshima

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

Junctophilins (JPs) contribute to the formation of junctional membrane complexes between the plasma membrane and the endoplasmic/sarcoplasmic reticulum, and provide a structural platform for channel communication during excitation-contraction coupling in muscle cells. In the brain, two neuronal JP subtypes are widely expressed in neurons. Recent studies have defined the essential role of neural JPs in the communication between cell-surface and intracellular channels, which modulates the excitability and synaptic plasticity of neurons in the cerebellum and hippocampus.

Original languageEnglish
Pages (from-to)385-391
Number of pages7
JournalCerebellum
Volume7
Issue number3
DOIs
Publication statusPublished - 2008 Sep

Keywords

  • Afterhyperpolarization
  • Ca release
  • Junctophilin
  • Long-term depression
  • Purkinje cell
  • Ryanodine receptor
  • Small-conductance Ca-activated K channel

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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