Functional and molecular characteristics of acute lymphoblastic leukemia cells with a mature T-cell phenotype from a patient with ataxia telangiectasia

Masayoshi Minegishi, Shigeru Tsuchiya, Naoko Minegishi, Masataka Nakamura, Tohru Abo, Toshiya Inaba, Tasuke Konno

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

A 12-year-old male patient with ataxia telangiectasia developed an acute lymphoblastic leukemia of T-cell pnenotype. The lymphoblasts showed uniform surface expression of CD3, CD7, CD8, and T-cell receptor (TCR) α/β chains, positive immunofluorescent staining of terminal deoxynucleotidyl transferase, complex cytogenetic aberrations including t(14;14) (q11;q32) and unique rearrangements of TCR β and γ chain genes, indicating the clonal expansion of leukemic cells. CD25 expression could be readily induced on the leukemic cells by mitogenic stimulation, followed by CD71 expression, but interleukin-2 production and subsequent proliferation in response to mitogens were subnormal.

Original languageEnglish
Pages (from-to)88-89
Number of pages2
JournalLeukemia
Volume5
Issue number1
Publication statusPublished - 1991 Jan

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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