Functional analysis of synthetic substructures of polytheonamide B: A transmembrane channel-forming peptide

Shigeru Matsuoka, Naoki Shinohara, Tomoaki Takahashi, Maiko Iida, Masayuki Inoue

    Research output: Contribution to journalArticlepeer-review

    14 Citations (Scopus)

    Abstract

    Longer is better: PolytheonamideB, the largest nonribosomal linear peptide identified to date, is a transmembrane channel-forming peptide. Nine of its substructures have now been chemically synthesized. The membrane-disrupting and ion-channel-forming sequences as well as the cytotoxicity-enhancing sequence have been identified.

    Original languageEnglish
    Pages (from-to)4879-4883
    Number of pages5
    JournalAngewandte Chemie - International Edition
    Volume50
    Issue number21
    DOIs
    Publication statusPublished - 2011 May 16

    Keywords

    • biological activity
    • ion channels
    • natural products
    • nonribosomal peptides
    • structure-activity relationships

    ASJC Scopus subject areas

    • Catalysis
    • Chemistry(all)

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