Functional analysis after auto iris pigment epithelial cell transplantation in patients with age-related macular degeneration

Toshiaki Abe, Madoka Yoshida, Hiroshi Tomita, Tetsuya Kano, Yoichi Nakagawa, Masami Sato, Yuko Wada, Nobuo Fuse, Tasuku Yamada, Makoto Tamai

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Recent transplantation studies indicate that subretinal space is not always an immunologically privileged site and non-autologous cells may be rejected in patients with exudative age-related macular degeneration (AMD). We performed autologous iris pigment epithelial (IPE) cell transplantation by cell suspension after autologous IPE cell culture in 8 patients with AMD. These patients were followed without immunosuppression between 1.5 and 8 months and the retinal function was analyzed. No cystoid macular edema or fluorescein leakage was observed. Six of the 8 patients improved visual acuity of more than two lines and the other two patients retained preoperative visual acuity. Five patients had increased visual field sensitivity, one patient retained pretransplantation sensitivity, and one patient showed a gradual decrease in sensitivity (one patient was not examined). Although 2 of the 8 patients showed decreased amplitude of flicker electroretinography (ERG) (about 60 to 70% as that of preoperative level), the average improvement of each amplitude of a single white flash (a wave), photopic, or flicker ERG was 123, 102, and 107%, respectively. No proliferative change in the submacular lesion or vitreous cavity was observed after transplantation. From this functional analysis, transplanted autologous IPE may have, in part, an alternative function in regard to the retinal pigment epithelium in the subretinal space. - auto iris pigment epithelium; rejection; transplantation

Original languageEnglish
Pages (from-to)295-305
Number of pages11
JournalTohoku Journal of Experimental Medicine
Volume189
Issue number4
DOIs
Publication statusPublished - 1999 Dec

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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