Function of type II phospholipase A2 in dopamine secretion by rat neuronal PC12 cells

Ichiro Kudo, Atsushi Matsuzawa, Kazuhiro Imai, Makoto Murakami, Keizo Inoue

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

When rat pheochromocytoma PC12 cells, which had differentiated into neuron-like cells following culture with nerve growth factor, were activated with glutamate, approximately 40% of their type II phospholipase A2 (PLA2) was released into the extracellular medium. Glutamate-stimulated secretion of dopamine from PC12 cells was suppressed by type II PLA2 inhibitors. Exogenous type II PLA2 added alone directly elicited release of dopamine from PC12 cells. Thus released type II PLA2 may be involved in the regulation of neurotransmitter exocytosis by PC12 cells.

Original languageEnglish
Pages (from-to)25-31
Number of pages7
JournalJournal of Lipid Mediators and Cell Signalling
Volume14
Issue number1-3
DOIs
Publication statusPublished - 1996 Sep
Externally publishedYes

Keywords

  • PC12 cells
  • dopamine
  • exocytosis
  • glutamate
  • phospholipase A

ASJC Scopus subject areas

  • Immunology
  • Pharmacology

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