Abstract
When rat pheochromocytoma PC12 cells, which had differentiated into neuron-like cells following culture with nerve growth factor, were activated with glutamate, approximately 40% of their type II phospholipase A2 (PLA2) was released into the extracellular medium. Glutamate-stimulated secretion of dopamine from PC12 cells was suppressed by type II PLA2 inhibitors. Exogenous type II PLA2 added alone directly elicited release of dopamine from PC12 cells. Thus released type II PLA2 may be involved in the regulation of neurotransmitter exocytosis by PC12 cells.
Original language | English |
---|---|
Pages (from-to) | 25-31 |
Number of pages | 7 |
Journal | Journal of Lipid Mediators and Cell Signalling |
Volume | 14 |
Issue number | 1-3 |
DOIs | |
Publication status | Published - 1996 Sep |
Externally published | Yes |
Keywords
- PC12 cells
- dopamine
- exocytosis
- glutamate
- phospholipase A
ASJC Scopus subject areas
- Immunology
- Pharmacology