Fulminant hepatic failure in a case of autoimmune hepatitis in hepatitis C during peg-inferferon-alpha 2b plus ribavirin treatment

Takayuki Kogure, Yoshiyuki Ueno, Koji Fukushima, Futoshi Nagasaki, Jun Inoue, Eiji Kakazu, Yasunori Matsuda, Osamu Kido, Yu Nakagome, Osamu Kimura, Noriyuki Obara, Yuta Wakui, Takao Iwasaki, Tooru Shimosegawa

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28 Citations (Scopus)

Abstract

A 27-year-old Caucasian female with hepatitis C virus (HCV) infection treated with interferon (IFN) who developed severe autoimmune hepatitis (AIH) is described. The infecting viral strain was of genotype Ib and the pre-treatment HCV viral load was at a high level. The patient was treated with pegylated IFN-alpha 2b and ribavirin, and her HCV-RNA became negative at wk 12, but after that she developed fulminant hepatic failure. The patient recovered after steroid pulse therapy consisting of methylprednisolone 1000 mg/d for three days which was administered twice. A needle liver biopsy revealed the typical pathological findings of AIH.

Original languageEnglish
Pages (from-to)4394-4397
Number of pages4
JournalWorld Journal of Gastroenterology
Volume13
Issue number32
DOIs
Publication statusPublished - 2007 Aug 28

Keywords

  • Acute liver failure
  • Anti-viral therapy A
  • Autoimmune hepatitis
  • Hepatitis C virus
  • Interferon
  • Ribavirin

ASJC Scopus subject areas

  • Gastroenterology

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  • Cite this

    Kogure, T., Ueno, Y., Fukushima, K., Nagasaki, F., Inoue, J., Kakazu, E., Matsuda, Y., Kido, O., Nakagome, Y., Kimura, O., Obara, N., Wakui, Y., Iwasaki, T., & Shimosegawa, T. (2007). Fulminant hepatic failure in a case of autoimmune hepatitis in hepatitis C during peg-inferferon-alpha 2b plus ribavirin treatment. World Journal of Gastroenterology, 13(32), 4394-4397. https://doi.org/10.3748/wjg.v13.i32.4394