Fullerene–Oligonucleotide Conjugates: Photoinduced Sequence‐Specific DNA Cleavage

Alexandre S. Boutorine, Masashi Takasugi, Claude Hélène, Hidetoshi Tokuyama, Hiroyuki Isobe, Eiichi Nakamura

Research output: Contribution to journalArticlepeer-review

252 Citations (Scopus)

Abstract

The guanine‐specific cleavage of oligonucleotides is achieved with the conjugate 1, which contains a fullerene tethered to a tetradecadeoxyribonucleotide Nu(pNu)n. This conjugate was able to form a duplex with a complementary oligonucleotide, and triplexes with appropriate double‐stranded oligonucleotides. Irradiation of the complexes leads to site‐specfic cleavage of the target sequences—probably through the action of singlet oxygen. (Figure Presented.)

Original languageEnglish
Pages (from-to)2462-2465
Number of pages4
JournalAngewandte Chemie International Edition in English
Volume33
Issue number23-24
DOIs
Publication statusPublished - 1995 Jan 3
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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