Full-length genomic sequence analysis of new subtype 3k hepatitis E virus isolates with 99.97% nucleotide identity obtained from two consecutive acute hepatitis patients in a city in northeast Japan

Masahito Miura, Jun Inoue, Mio Tsuruoka, Tsutomu Nishizawa, Shigeo Nagashima, Masaharu Takahashi, Tooru Shimosegawa, Hiroaki Okamoto

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Full-length genomic sequences of hepatitis E virus (HEV) obtained from two consecutive cases of acute self-limiting hepatitis E in a city in northeast Japan were determined. Interestingly, two HEV isolates from each patient shared nucleotide identity of 99.97% in 7 225 nucleotides, and a phylogenetic analysis showed that they formed a cluster of Japanese isolates that is considered as a new HEV subtype 3k. The high similarity of HEV sequences of two isolates from these patients in this study suggested that a subtype 3k HEV strain had spread via a commonly distributed food in the city, possibly pig liver.

Original languageEnglish
Pages (from-to)1116-1120
Number of pages5
JournalJournal of Medical Virology
Volume89
Issue number6
DOIs
Publication statusPublished - 2017 Jun 1

Keywords

  • full genome
  • genotype 3
  • hepatitis viruses
  • phylogenetic analysis
  • subtype classification

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

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