Full automatic synthesis of [18F]THK-5351 for tau protein PET imaging in Alzheimer’s disease patients: 1 year experience

Sang Ju Lee, Seung Jun Oh, Eun Hye Cho, Da Hye Kim, Shozo Furumoto, Nobuyuki Okamura, Jae Seung Kim

Research output: Contribution to journalArticle

Abstract

[18F]THK-5351, a new candidate for tau protein imaging, is based on an aryl quinoline structure. We report the full automatic synthesis using disposable cassettes under pH controlled [18F]fluorination. After the trapping of 88.5 ± 21.9 GBq of [18F]fluoride, it was eluted with potassium methansulfonate (KOMs) (pH 7.8)/K222. After drying, 3 mg of the precursor was added to 1 mL DMSO and subjected to [18F]fluorination at 110 °C for 10 min. After hydrolysis, the final product was purified by HPLC. The overall radiochemical yield was 31.9 ± 11.1% (n = 22), satisfying all quality control criteria. It was stable for up to 6 h with high radiochemical purity as 99.8 ± 0.5%.

Original languageEnglish
Pages (from-to)1587-1593
Number of pages7
JournalJournal of Radioanalytical and Nuclear Chemistry
Volume314
Issue number3
DOIs
Publication statusPublished - 2017 Dec 1

Keywords

  • Automatic synthesis
  • PET imaging
  • THK-5351
  • Tau protein positron emission tomography
  • [F]fluorination

ASJC Scopus subject areas

  • Analytical Chemistry
  • Nuclear Energy and Engineering
  • Radiology Nuclear Medicine and imaging
  • Pollution
  • Spectroscopy
  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

Fingerprint Dive into the research topics of 'Full automatic synthesis of [<sup>18</sup>F]THK-5351 for tau protein PET imaging in Alzheimer’s disease patients: 1 year experience'. Together they form a unique fingerprint.

  • Cite this