Fukushima simulation experiment: Assessing the effects of chronic low-dose-rate internal 137Cs radiation exposure on litter size, sex ratio, and biokinetics in mice

Hiroo Nakajima, Yoshiaki Yamaguchi, Takashi Yoshimura, Manabu Fukumoto, Takeshi Todo

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

To investigate the transgenerational effects of chronic low-dose-rate internal radiation exposure after the Fukushima Daiichi Nuclear Power Plant accident in Japan, 18 generations of mice were maintained in a radioisotope facility, with free access to drinking water containing 137CsCl (0 and 100 Bq/ml). The 137Cs distribution in the organs of the mice was measured after long-term ad libitum intake of the 137CsCl water. The litter size and the sex ratio of the group ingesting the 137Cs water were compared with those of the control group, for all 18 generations of mice. No significant difference was noted in the litter size or the sex ratio between the mice in the control group and those in the group ingesting the 137Cs water. The fixed internal exposure doses were ∼160 Bq/g and 80 Bq/g in the muscles and other organs, respectively.

Original languageEnglish
Pages (from-to)i29-i35
JournalJournal of radiation research
Volume56
DOIs
Publication statusPublished - 2015 Dec 1

Keywords

  • Cesium
  • Fukushima simulation experiment
  • chronic low-dose rate
  • internal radiation exposure
  • mice
  • transgenerational effects

ASJC Scopus subject areas

  • Radiation
  • Radiology Nuclear Medicine and imaging
  • Health, Toxicology and Mutagenesis

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