Fucosyltransferase 8. GDP-fucose N-glycan core α6-fucosyltransferase (FUT8)

Hideyuki Ihara, Hiroki Tsukamoto, Jianguo Gu, Eiji Miyoshi, Naoyuki Taniguchi, Yoshitaka Ikeda

Research output: Chapter in Book/Report/Conference proceedingChapter

7 Citations (Scopus)

Abstract

α1,6-Fucosylation of asparagine-linked oligosaccharides (N-glycans) is ubiquitously observed in eukaryote except plant and fungi. This type of fucosylation is catalyzed by eukaryotic α1,6-fucosyltransferase, and this enzyme is called as FUT8, notably in mammalian. FUT8 transfers fucose moiety from GDP-β-L-fucose to the innermost GlcNAc residue in N-glycan (Fig. 59.1). FUT8 was purified from porcine brain (Uozumi et al. 1996b) and MKN45 cells, a human gastric cancer cell line (Yanagidani et al. 1997). The cDNAs were successfully cloned from porcine and human (Uozumi et al. 1996b; Yanagidani et al. 1997). α1,6-Fucosylation catalyzed by FUT8 and the resulting α1,6-fucose residue is denoted as core fucosylation and core fucose, respectively.

Original languageEnglish
Title of host publicationHandbook of Glycosyltransferases and Related Genes, Second Edition
PublisherSpringer Japan
Pages581-596
Number of pages16
Volume1
ISBN (Electronic)9784431542407
ISBN (Print)9784431542391
DOIs
Publication statusPublished - 2014 Jan 1

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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