Fucosyltransferase 8. GDP-fucose N-glycan core α6-fucosyltransferase (FUT8)

Hideyuki Ihara, Hiroki Tsukamoto, Jianguo Gu, Eiji Miyoshi, Naoyuki Taniguchi, Yoshitaka Ikeda

Research output: Chapter in Book/Report/Conference proceedingChapter

11 Citations (Scopus)


α1,6-Fucosylation of asparagine-linked oligosaccharides (N-glycans) is ubiquitously observed in eukaryote except plant and fungi. This type of fucosylation is catalyzed by eukaryotic α1,6-fucosyltransferase, and this enzyme is called as FUT8, notably in mammalian. FUT8 transfers fucose moiety from GDP-β-L-fucose to the innermost GlcNAc residue in N-glycan (Fig. 59.1). FUT8 was purified from porcine brain (Uozumi et al. 1996b) and MKN45 cells, a human gastric cancer cell line (Yanagidani et al. 1997). The cDNAs were successfully cloned from porcine and human (Uozumi et al. 1996b; Yanagidani et al. 1997). α1,6-Fucosylation catalyzed by FUT8 and the resulting α1,6-fucose residue is denoted as core fucosylation and core fucose, respectively.

Original languageEnglish
Title of host publicationHandbook of Glycosyltransferases and Related Genes, Second Edition
PublisherSpringer Japan
Number of pages16
ISBN (Electronic)9784431542407
ISBN (Print)9784431542391
Publication statusPublished - 2014 Jan 1

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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