FTS reduces bleomycin-induced cytokine and chemokine production and inhibits pulmonary fibrosis in mice

S. Yara, Kazuyoshi Kawakami, N. Kudeken, M. Tohyama, K. Teruya, T. Chinen, A. Awaya, A. Saito

Research output: Contribution to journalArticlepeer-review

49 Citations (Scopus)

Abstract

Bleomycin (BLM), an antitumour drug, is known to cause interstitial pneumonia followed by pulmonary fibrosis, and has often been used to produce an animal model of pulmonary fibrosis. In the present study, we examined the effect of a nonapeptide thymic hormone, facteur thymique serique (FTS), on the murine lung fibrosis induced by intratracheal instillation of BLM. Treatment with FTS ameliorated BLM-induced fibrotic changes in a dose-dependent manner, as indicated by the reduced accumulation of hydroxyproline (HP). In addition, FTS suppressed BLM-induced cellular inflammatory response in the lungs, as evidenced by inhibition of increased lung weight, reduced accumulation of inflammatory leucocytes, including lymphocytes and neutrophils, but not macrophages, and less pronounced histopathological changes. Finally, BLM challenge increased the local synthesis of proinflammatory cytokines, TNF-a and IL-1β and chemokines, MCP-1, MIP-1α RANTES, MIP-2 and KC, while administration of FTS suppressed the production of these cytokines, except for MCP-1. These effects of FTS were observed only when mice received intratracheal instillation with BLM. Considered collectively, our results indicated that FTS treatment ameliorated the cellular inflammatory responses and fibrotic changes in the lungs caused by BLM and such inhibition was well correlated with reduced synthesis of several fibrosis-related cytokines, and suggested that FTS may be potentially useful for the treatment of pulmonary fibrosis.

Original languageEnglish
Pages (from-to)77-85
Number of pages9
JournalClinical and Experimental Immunology
Volume124
Issue number1
DOIs
Publication statusPublished - 2001
Externally publishedYes

Keywords

  • Bleomycin
  • Chemokines
  • Proinflammatory cytokines
  • Pulmonary fibrosis
  • Thymic hormone

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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