Fruit and vegetable consumption and risk of colorectal cancer in Japan: The Miyagi cohort study

Yuki Sato, Yoshitaka Tsubono, Naoki Nakaya, Keiko Ogawa, Kayoko Kurashima, Shinichi Kuriyama, Atsushi Hozawa, Yoshikazu Nishino, Daisuke Shibuya, Ichiro Tsuji

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)

Abstract

Objective: Adequate fruit and vegetable intake has been suggested to protect against colorectal cancer. However, several recent prospective studies have reported no association. We therefore examined the association between fruit and vegetable intakes and the risk of colorectal cancer in a prospective cohort study in Japan. Design: Between June and August 1990, 47 605 Japanese men and women completed a self-administered questionnaire, including a food-frequency questionnaire. We divided the subjects into quartiles based on their self-reported fruit and vegetable consumption. There were 165 colon cancer and 110 rectal cancer incidences identified during 7 years of follow-up, to the end of December 1997. We used Cox proportional hazards models to estimate the relative risk (RR) of developing colorectal cancer according to the level of fruit and vegetable consumption, applying adjustments for potential confounders. Results: No statistically significant association was observed between fruit and vegetable consumption and the risk of colorectal cancer. The multivariate RR of colon cancer in the highest quartile of fruit and vegetable intake compared with the lowest was 1.13 (95% confidence interval (CI) 0.73-1.75), the RR for vegetables alone was 1.24 (95% CI 0.79-1.95) and that for fruit alone was 1.45 (95% CI 0.85-2.47). The corresponding multivariate RRs for rectal cancer were 1.12 (95% CI 0.67-1.89), 1.14 (95% CI 0.67-1.93) and 1.41 (95% CI 0.73-2.73). Conclusions: We found no association between the consumption of fruit and vegetables and the risk of colorectal cancer among the Japanese population.

Original languageEnglish
Pages (from-to)309-314
Number of pages6
JournalPublic Health Nutrition
Volume8
Issue number3
DOIs
Publication statusPublished - 2005 May

Keywords

  • Colorectal cancer
  • Food-frequency questionnaire
  • Fruit
  • Prospective cohort study
  • Vegetables

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Public Health, Environmental and Occupational Health

Fingerprint Dive into the research topics of 'Fruit and vegetable consumption and risk of colorectal cancer in Japan: The Miyagi cohort study'. Together they form a unique fingerprint.

Cite this