Frontal-lobe syndrome and psychosis after damage to the brainstem dopaminergic nuclei

Yoshiyuki Nishio, Kazunari Ishii, Hiroaki Kazui, Yoshiyuki Hosokai, Etsuro Mori

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)


A patient developed frontal-lobe syndrome and psychotic symptoms after infarction in the pontomesencephalic junction. Stereotaxic lesion localization on magnetic resonance imaging and statistical analyses of regional cerebral blood flow (rCBF) disclosed an involvement of the rostral brainstem dopaminergic nuclei and hypoperfusion in the frontal-subcortical circuit components. We suggest that the patient's cognitive and behavioral disturbances were associated with disruption of ascending dopaminergic projections to the frontal-subcortical circuits.

Original languageEnglish
Pages (from-to)271-274
Number of pages4
JournalJournal of the neurological sciences
Issue number1-2
Publication statusPublished - 2007 Sep 15


  • Frontal-lobe syndorome
  • Frontal-subcortical circuits
  • Hallucinations
  • Mesocorticolimbic dopaminergic system
  • Rostral brainstem

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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