From vesicles to protocells: The roles of amphiphilic molecules

Research output: Contribution to journalReview article

20 Citations (Scopus)

Abstract

It is very challenging to construct protocells from molecular assemblies. An important step in this challenge is the achievement of vesicle dynamics that are relevant to cellular functions, such as membrane trafficking and self-reproduction, using amphiphilic molecules. Soft matter physics will play an important role in the development of vesicles that have these functions. Here, we show that simple binary phospholipid vesicles have the potential to reproduce the relevant functions of adhesion, pore formation and self-reproduction of vesicles, by coupling the lipid geometries (spontaneous curvatures) and the phase separation. This achievement will elucidate the pathway from molecular assembly to cellular life.

Original languageEnglish
Pages (from-to)651-675
Number of pages25
JournalLife
Volume5
Issue number1
DOIs
Publication statusPublished - 2015 Mar 2

Keywords

  • Adhesion
  • Deformation
  • Phase separation
  • Pore formation
  • Protocell
  • Self-reproduction
  • Spontaneous curvature
  • Vesicle

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Biochemistry, Genetics and Molecular Biology(all)
  • Space and Planetary Science
  • Palaeontology

Fingerprint Dive into the research topics of 'From vesicles to protocells: The roles of amphiphilic molecules'. Together they form a unique fingerprint.

  • Cite this