From molecular footprints of disease to new therapeutic interventions in diabetic nephropathy: A detective story

Toshio Miyata, Kiyoshi Kurokawa, Charles van Ypersele de Strihou

Research output: Contribution to journalReview articlepeer-review

3 Citations (Scopus)

Abstract

Oxidative tissue damage in vivo is a complex phenomenon involving many factors and pathways. Proteins are particularly attractive targets for oxidative products analysis in order to understand better the physiopathology of human diseases. Protein modifications serve as footprints of biochemical processes. They also help ascertain the mechanism of anti-oxidative action of medical drugs and further search for novel agents that inhibit efficiently oxidative protein damage. Several drugs already used clinically interfere with oxidative protein damage through different mechanisms characteristic of their chemical structure. This review delineates the oxidative protein modifications existing in diabetic nephropathy and their regression in association with renoprotective anti-hypertensive agents. Our hypothetical approach will require further testing. Nevertheless, the insights gained on the biochemistry of protein modifications open new avenues towards the development of new classes of renoprotective agents for diabetic nephropathy.

Original languageEnglish
Pages (from-to)323-329
Number of pages7
JournalCurrent Drug Targets: Immune, Endocrine and Metabolic Disorders
Volume5
Issue number3
DOIs
Publication statusPublished - 2005 Sep 1
Externally publishedYes

Keywords

  • Anti-hypertensive agent
  • Carbonyl stress
  • Metabolic derangement
  • Oxidative stress
  • Protein modification advanced glycation end product
  • Renoprotection

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Immunology and Allergy

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