Friedel-Crafts-type alkylation in aqueous media using resin-supported peptide catalyst having polyleucine

Kengo Akagawa, Takuhiro Yamashita, Seiji Sakamoto, Kazuaki Kudo

Research output: Contribution to journalArticlepeer-review

38 Citations (Scopus)

Abstract

The asymmetric Friedel-Crafts-type alkylation in aqueous media was realized by the resin-supported N-terminal prolyl peptide catalyst having a polyleucine tether. The hydrophobic polyleucine chain in the peptide catalyst was essential for the reaction efficiency and enantioselectivity. The resin-bound peptide catalyst could be reused at least for five times.

Original languageEnglish
Pages (from-to)5602-5604
Number of pages3
JournalTetrahedron Letters
Volume50
Issue number40
DOIs
Publication statusPublished - 2009 Oct 7

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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