Abstract
The asymmetric Friedel-Crafts-type alkylation in aqueous media was realized by the resin-supported N-terminal prolyl peptide catalyst having a polyleucine tether. The hydrophobic polyleucine chain in the peptide catalyst was essential for the reaction efficiency and enantioselectivity. The resin-bound peptide catalyst could be reused at least for five times.
Original language | English |
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Pages (from-to) | 5602-5604 |
Number of pages | 3 |
Journal | Tetrahedron Letters |
Volume | 50 |
Issue number | 40 |
DOIs | |
Publication status | Published - 2009 Oct 7 |
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry