Frequent frameshift mutations of RIZ in sporadic gastrointestinal and endometrial carcinomas with microsatellite instability

Z. Piao, W. Fang, S. Malkhosyan, H. Kim, A. Horii, M. Perucho, S. Huang

Research output: Contribution to journalArticlepeer-review

77 Citations (Scopus)

Abstract

Many lines of evidence suggest that the retinoblastoma protein interacting zinc finger gene RIZ is a strong candidate for the tumor suppressor locus on 1p36, a region commonly deleted in many human cancers with chromosomal instability. In addition, a role for RIZ in tumors of the microsatellite instability pathway is suggested by frequent frameshift mutations in hereditary non-polyposis colorectal carcinomas. Here we studied RIZ mutations in sporadic cancers with microsatellite instability. Frameshift mutations in the two coding polyadenosine tracks of RIZ were found in 19 (48%) of 40 gastric carcinomas, 6 (33%) of 18 endometrial carcinomas, 14 (26%) of 51 of colorectal carcinomas, and 7 (54%) of 13 cell lines. Eleven tumor tissues showed biallelic inactivation of RIZ. In contrast, no frameshift mutations were found in 70 microsatellite stable tumors. These results suggest an important role for RIZ in sporadic cancers with microsatellite instability.

Original languageEnglish
Pages (from-to)4701-4704
Number of pages4
JournalCancer Research
Volume60
Issue number17
Publication statusPublished - 2000 Sep 1

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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