Frequency and hemostatic abnormalities in pre-DIC patients

Kohji Okamoto, Hideo Wada, Tsuyoshi Hatada, Toshimasa Uchiyama, Kazuo Kawasugi, Toshihiko Mayumi, Satoshi Gando, Shigeki Kushimoto, Yoshinobu Seki, Seiji Madoiwa, Hidesaku Asakura, Shin Koga, Toshiaki Iba, Ikuro Maruyama

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15 Citations (Scopus)

Abstract

Disseminated intravascular coagulation (DIC) sometimes has a poor outcome, and therefore early diagnosis and treatment are required. This study prospectively evaluated the hemostatic abnormalities and the onset of DIC in 613 patients with underlying diseases to identify a useful marker for diagnosing Pre-DIC. Pre-DIC was defined as the condition of patients within a week before the onset of DIC. Initially, 34.4% of patients were diagnosed with DIC, and about 8.5% of the patients without DIC were diagnosed as DIC within a week after registration (pre-DIC). The mortality of DIC, Pre-DIC and "without DIC" was 35.3%, 32.4% and 17.2%, respectively. All hemostatic parameters were significantly worse in "DIC" than "without DIC" and the values of the prothrombin time ratio, platelet count and fibrin monomer complex could classify the three groups; "DIC", "pre-DIC" and "without DIC". No useful marker was identified that provided an adequate cutoff value to differentiate "pre-DIC" from "without DIC". A multivariate analysis identified clinical symptoms that were related to poor outcome. DIC must be treated immediately; there is no specific marker to identify pre-DIC.

Original languageEnglish
Pages (from-to)74-78
Number of pages5
JournalThrombosis Research
Volume126
Issue number1
DOIs
Publication statusPublished - 2010 Jul

Keywords

  • DIC
  • Hemostatic markers
  • Mortality
  • Pre-DIC
  • Resolution rate

ASJC Scopus subject areas

  • Hematology

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    Okamoto, K., Wada, H., Hatada, T., Uchiyama, T., Kawasugi, K., Mayumi, T., Gando, S., Kushimoto, S., Seki, Y., Madoiwa, S., Asakura, H., Koga, S., Iba, T., & Maruyama, I. (2010). Frequency and hemostatic abnormalities in pre-DIC patients. Thrombosis Research, 126(1), 74-78. https://doi.org/10.1016/j.thromres.2010.03.017