Fractional exhaled nitric oxide (FeNO) and spirometry as indicators of inhalation exposure to chemical agents in pathology workers

Ritsuko Arakawa Suzuki, Toshiya Irokawa, Hiromasa Ogawa, Shinya Ohkouchi, Masao Tabata, Susumu Togashi, Takeshi Nakamura, Noriko Ohisa, Etsuhiro Nikkuni, Emiri Miura, Kaoru Yoshida, Hiroshi Inomata, Hajime Kurosawa

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Objective: The objective of this study was to examine whether fractional exhaled nitric oxide (FeNO) and spirometry can be used as indices to evaluate adverse health effects of low-concentrated chemical inhalation exposure, mainly to formaldehyde. Methods: Thirty-three subjects (pathology technicians) and 30 controls (workers without handling any chemicals in the same hospitals) participated in this study. All participants underwent FeNO measurement and spirometry before and after 5 days of work. Results: FeNO significantly increased in the subjects with a history of asthma (P<0.05), whereas forced vital capacity (FVC) and forced expiratory volume in the first second (FEV1) decreased in the subjects (P<0.05). Furthermore, work duration and pre-work levels of FEV1 in the subjects had a significant association. Conclusion: The results suggest that FeNO, FVC, and FEV1 represent effective health-effect indices of low-concentrated chemical inhalation exposure.

Original languageEnglish
Pages (from-to)467-473
Number of pages7
JournalJournal of Occupational and Environmental Medicine
Volume59
Issue number5
DOIs
Publication statusPublished - 2017

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Fingerprint

Dive into the research topics of 'Fractional exhaled nitric oxide (FeNO) and spirometry as indicators of inhalation exposure to chemical agents in pathology workers'. Together they form a unique fingerprint.

Cite this