Four-dimensional measurement of the displacement of internal fiducial markers during 320-multislice computed tomography scanning of thoracic esophageal cancer

Hideomi Yamashita, Satoshi Kida, Akira Sakumi, Akihiro Haga, Saori Ito, Tsuyoshi Onoe, Kae Okuma, Kenji Ino, Masaaki Akahane, Kuni Ohtomo, Keiichi Nakagawa

Research output: Contribution to journalArticlepeer-review

49 Citations (Scopus)

Abstract

Purpose: To investigate the three-dimensional movement of internal fiducial markers placed near esophageal cancers using 320-multislice CT. Methods and Materials: This study examined 22 metal markers in the esophageal wall near the primary tumors of 12 patients treated with external-beam photon radiotherapy. Motion assessment was analyzed in 41 respiratory phases during 20 s of cine CT in the radiotherapy position. Results: Motion in the cranial-caudal (CC) direction showed a strong correlation (R2 > 0.4) with the respiratory curve in most markers (73%). The average absolute amplitude of the marker movement was 1.5 ± 1.6 mm, 1.6 ± 1.7 mm, and 3.3 ± 3.3 mm in the left-right (LR), anterior-posterior (AP), and CC directions, respectively. The average marker displacements in the CC direction between peak exhalation and inhalation for the 22 clips were 1.1 mm (maximum, 5.5 mm), 3.0 mm (14.5 mm), and 5.1 mm (16.3 mm) for the upper, middle, and lower thoracic esophagus, respectively. Conclusions: Motion in primary esophagus tumor was evaluated with 320-multislice CT. According to this study, 4.3 mm CC, 1.5 mm AP, and 2.0 mm LR in the upper, 7.4 mm CC, 3.0 mm AP, and 2.4 mm LR in the middle, and 13.8 mm CC, 6.6 mm AP, and 6.8 mm LR in the lower thoracic esophagus provided coverage of tumor motion in 95% of the cases in our study population.

Original languageEnglish
Pages (from-to)588-595
Number of pages8
JournalInternational Journal of Radiation Oncology Biology Physics
Volume79
Issue number2
DOIs
Publication statusPublished - 2011 Feb 1

Keywords

  • Computed tomography
  • Esophageal cancer
  • Internal margin
  • Intrafraction motion

ASJC Scopus subject areas

  • Radiation
  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

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