Abstract
Fully substituted triazoles were synthesized via the four-component coupling reaction of unactivated silylacetylenes, two equivalents of allyl carbonates, and trimethylsilyl azide in the presence of a Pd(0)-Cu(I) bimetallic catalyst. Various trisubstituted 1,2,3-triazoles were obtained in good yields. The reaction most probably proceeds through the [3+2] cycloaddition reaction between the alkynylcopper species and azide followed by the cross-coupling reaction between the vinylcopper intermediate and π-allylpalladium complex.
Original language | English |
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Pages (from-to) | 689-691 |
Number of pages | 3 |
Journal | Tetrahedron Letters |
Volume | 45 |
Issue number | 4 |
DOIs | |
Publication status | Published - 2004 Jan 19 |
Keywords
- Bimetallic catalyst
- Copper catalyst
- Four-component coupling
- Palladium catalyst
- TMS-azide
- Triazole
- π-Allylpalladium complex
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry