Forskolin Preferentially Dilates the Afferent Arteriole in the Canine Kidney

Toshiaki Tamaki, Kouichi Hasui, Tetsuo Shoji, Yasuharu Aki, Hideyasu Kiyomoto, Hiroshi Iwao, Youichi Abe

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Intrarenal infusion of forskolin (0,2μg/kg/min) in anesthetized dogs increased renal blood flow (RBF) and glomerular filtration rate (GFR) to the same degree but did not change the mean arterial pressure or heart rate. Forskolin also increased urine flow and urinary sodium excretion. The proportional increases in RBF and GFR may result from a preferential action of forskolin to dilate the afferent arteriole.

Original languageEnglish
Pages (from-to)161-164
Number of pages4
JournalThe Japanese Journal of Pharmacology
Volume55
Issue number1
DOIs
Publication statusPublished - 1991 Jan

ASJC Scopus subject areas

  • Pharmacology

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