Formation of xanthone oxime and related compounds using a combination of tert-butyl nitrite and potassium hexamethyldisilazide

Yusuke Iwama, Takahiro Noro, Kentaro Okano, Hidetsura Cho, Hidetoshi Tokuyama

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Synthesis of xanthone oxime and related compounds via nitrosation of the dibenzylic position using a combination of tert-butyl nitrite and potassium hexamethyldisilazide is described. The reaction conditions are effective for the synthesis of xanthone oxime as well as thioxanthone, acridone, and anthrone oximes, which have been difficult to synthesize from the corresponding ketones by conventional dehydrative condensation with hydroxylamine.

Original languageEnglish
Pages (from-to)1433-1444
Number of pages12
JournalHeterocycles
Volume8
Issue number2
DOIs
Publication statusPublished - 2014 Jan 1

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

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