Formation of highly selective and efficient interstrand cross-linking to thymine without photo-irradiation

Keiichi Hattori; Tomoya Hirohama; Shuhei Imoto; Shuhei Kusano; Fumi Nagatsugi

doi:10.1039/b915381k

Formation of highly selective and efficient interstrand cross-linking to thymine without photo-irradiation

Keiichi Hattori, Tomoya Hirohama, Shuhei Imoto, Shuhei Kusano, Fumi Nagatsugi

Division of Organic- and Biomaterials Research

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Abstract

Interstrand cross-linking (ICL) forming oligodeoxynucleotides (ODNs) have been expected to ensure the inhibition of gene expression. In this communication, we report a highly efficient and selective ICL reaction to thymine using a 4-amino-2-vinyl-6-oxopyrimidine derivative.

Original language	English
Pages (from-to)	6463-6465
Number of pages	3
Journal	Chemical Communications
Issue number	42
DOIs	https://doi.org/10.1039/b915381k
Publication status	Published - 2009

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/b915381k

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title = "Formation of highly selective and efficient interstrand cross-linking to thymine without photo-irradiation",

abstract = "Interstrand cross-linking (ICL) forming oligodeoxynucleotides (ODNs) have been expected to ensure the inhibition of gene expression. In this communication, we report a highly efficient and selective ICL reaction to thymine using a 4-amino-2-vinyl-6-oxopyrimidine derivative.",

author = "Keiichi Hattori and Tomoya Hirohama and Shuhei Imoto and Shuhei Kusano and Fumi Nagatsugi",

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journal = "Chemical Communications",

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T1 - Formation of highly selective and efficient interstrand cross-linking to thymine without photo-irradiation

AU - Hattori, Keiichi

AU - Hirohama, Tomoya

AU - Imoto, Shuhei

AU - Kusano, Shuhei

AU - Nagatsugi, Fumi

PY - 2009

Y1 - 2009

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AB - Interstrand cross-linking (ICL) forming oligodeoxynucleotides (ODNs) have been expected to ensure the inhibition of gene expression. In this communication, we report a highly efficient and selective ICL reaction to thymine using a 4-amino-2-vinyl-6-oxopyrimidine derivative.

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DO - 10.1039/b915381k

M3 - Article

C2 - 19841810

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JO - Chemical Communications

JF - Chemical Communications

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ER -

Formation of highly selective and efficient interstrand cross-linking to thymine without photo-irradiation

Abstract

ASJC Scopus subject areas

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