Formation of highly selective and efficient interstrand cross-linking to thymine without photo-irradiation

Keiichi Hattori, Tomoya Hirohama, Shuhei Imoto, Shuhei Kusano, Fumi Nagatsugi

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)

Abstract

Interstrand cross-linking (ICL) forming oligodeoxynucleotides (ODNs) have been expected to ensure the inhibition of gene expression. In this communication, we report a highly efficient and selective ICL reaction to thymine using a 4-amino-2-vinyl-6-oxopyrimidine derivative.

Original languageEnglish
Pages (from-to)6463-6465
Number of pages3
JournalChemical Communications
Issue number42
DOIs
Publication statusPublished - 2009

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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