Formation of genotoxic bifunctional electrophiles from arachidonic acid hydroperoxides

Michelle V. Williams, Seon Hwa Lee, Tomoyuki Oe, Ian A. Blair

Research output: Contribution to conferencePaper

Abstract

The formation of genotoxic bifunctional electrophiles from arachidonic acid hydroperoxides during vitamin C-mediated decomposition was investigated. The normal phase LC/tandem mass spectrometry analysis (MS/MS) were used for the study. It was found that the reaction with vitamin C and 15-HpETE produced a product profile that was distinct in its major products produced. It was also found that vitamin E was just as potent as vitamin C in mediating the formation of bifunctional electrophiles.

Original languageEnglish
Pages607-608
Number of pages2
Publication statusPublished - 2002 Dec 1
Externally publishedYes
EventProceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics - Orlando, FL, United States
Duration: 2002 Jun 22002 Jun 6

Other

OtherProceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics
CountryUnited States
CityOrlando, FL
Period02/6/202/6/6

ASJC Scopus subject areas

  • Spectroscopy

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  • Cite this

    Williams, M. V., Lee, S. H., Oe, T., & Blair, I. A. (2002). Formation of genotoxic bifunctional electrophiles from arachidonic acid hydroperoxides. 607-608. Paper presented at Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics, Orlando, FL, United States.