The formation of genotoxic bifunctional electrophiles from arachidonic acid hydroperoxides during vitamin C-mediated decomposition was investigated. The normal phase LC/tandem mass spectrometry analysis (MS/MS) were used for the study. It was found that the reaction with vitamin C and 15-HpETE produced a product profile that was distinct in its major products produced. It was also found that vitamin E was just as potent as vitamin C in mediating the formation of bifunctional electrophiles.
|Number of pages||2|
|Publication status||Published - 2002 Dec 1|
|Event||Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics - Orlando, FL, United States|
Duration: 2002 Jun 2 → 2002 Jun 6
|Other||Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics|
|Period||02/6/2 → 02/6/6|
ASJC Scopus subject areas