TY - GEN
T1 - Formation of DNA micro-skeleton structures in water-in-oil microdroplets
AU - Morita, Masamune
AU - Nomura, Shin Ichiro M.
AU - Murata, Satoshi
AU - Yanagisawa, Miho
AU - Takinoue, Masahiro
N1 - Funding Information:
We thank Prof. M. Ichikawa (Kyoto Univ.), Prof. T. Hamada (JAIST), Prof. K. Yoshikawa (Doshisha Univ.),? and Prof. K. Okabe (Univ. Tokyo) for fruitful discussions. This work was supported by a Grant-in-Aid for Scientific Research on Innovative Area “Molecular Robotics” (No. 24104002 (M.T.), No. 25104522 (M.Y.), No. 24104004 (S.M.N), No. 24104005 (S.M.)) and a Leading Initiative for Excellent Young Researchers (16812285) (M.M.) from the Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan; and Grant-in-Aid for Scientific Research B (No. 26280097, No. 17H01813) (M.T.), Scientific Research on Innovative Areas (No. 16K12521) (M.T.), Scientific Research S (No. 22220001) (S.M. and M.T.), Young Scientists B (No. 16K21034) (M.M.) and a Research Fellowship for Young Scientists (14J10002) from the Japan Society for the Promotion of Science (JSPS)
Publisher Copyright:
© 17CBMS-0001.
PY - 2020
Y1 - 2020
N2 - We show a novel DNA microstructure, named “DNA micro-skeleton”. This DNA microstructure is constructed by self-assembly of Y-motif DNA inside water-in-oil microdroplets covered with cationic lipids. The DNA micro-skeleton is a porous and hollow microcapsule with a large surface area. Therefore, we believe the structure will have potentials for physical and biomedical use such as artificial cells and molecular robots, which will be realized by the advantage of the soft but robust structure and also its large surface area.
AB - We show a novel DNA microstructure, named “DNA micro-skeleton”. This DNA microstructure is constructed by self-assembly of Y-motif DNA inside water-in-oil microdroplets covered with cationic lipids. The DNA micro-skeleton is a porous and hollow microcapsule with a large surface area. Therefore, we believe the structure will have potentials for physical and biomedical use such as artificial cells and molecular robots, which will be realized by the advantage of the soft but robust structure and also its large surface area.
KW - DNA hydrogel
KW - DNA nanotechnology
KW - Self-assembly
KW - Water-in-oil droplets
UR - http://www.scopus.com/inward/record.url?scp=85079620553&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85079620553&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:85079620553
T3 - 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
SP - 159
EP - 160
BT - 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
PB - Chemical and Biological Microsystems Society
T2 - 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
Y2 - 22 October 2017 through 26 October 2017
ER -