Formation of bone-like apatite on organic polymers treated with a silane-coupling agent and a titania solution

Francisco Balas, Masakazu Kawashita, Takashi Nakamura, Tadashi Kokubo

Research output: Contribution to journalArticlepeer-review

39 Citations (Scopus)

Abstract

Polyethylene terephthalate (PET), ethylene-vinyl alcohol copolymer (EVOH) and Nylon 6 in plate form were treated with silane-coupling agents, a titanium alkoxide-alcohol solution and a hot HCl solution to form a thin crystalline titanium oxide layer. When placed in a simulated body fluid with ion concentrations nearly equal to those of the human blood plasma, nanosized bone-like apatite formed uniformly on the surfaces of these treated polymers: within 2 days for PET and Nylon 6, and 7 days for EVOH. This indicates that such titania-modified polymers might form bone-like apatite in the living body, and bond to living bone through this apatite layer. Three-dimensional fabrics of these polymer fibers, with open spaces in various sizes, are expected to be useful as bone substitutes, as they will be integrated with the natural bone.

Original languageEnglish
Pages (from-to)1704-1710
Number of pages7
JournalBiomaterials
Volume27
Issue number9
DOIs
Publication statusPublished - 2006 Mar 1

Keywords

  • Apatite
  • Bioactive materials
  • Polyethylene terephthalate
  • Surface modification
  • Titanium oxide

ASJC Scopus subject areas

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

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