Formal synthesis of hepatitis C Virus NS5B polymerase inhibitor

Takahiro Noro, Kentaro Okano, Hidetoshi Tokuyama

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

A formal synthesis of a hepatitis C virus (HCV) inhibitor is described. The synthesis features a benzyne-mediated one-pot indoline formation-methylation sequence and an In(OTf)3-mediated mild oxa-Pictet-Spengler reaction for the synthesis of substituted electron-rich pyranoindole.

Original languageEnglish
Article numberST-2013-U0562-L
Pages (from-to)2143-2147
Number of pages5
JournalSynlett
Volume24
Issue number16
DOIs
Publication statusPublished - 2013 Aug 28

Keywords

  • benzyne
  • magnesium
  • one-pot
  • tandem reaction
  • total synthesis

ASJC Scopus subject areas

  • Organic Chemistry

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