Formal Synthesis of Ezetimibe Using a Proline-mediated, Asymmetric, Three-component Mannich Reaction

Yasuharu Shimasaki, Seitaro Koshino, Yujiro Hayashi

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

The formal total synthesis of ezetimibe was accomplished using a proline-mediated, asymmetric, three-component Mannich reaction as the key step. The two stereogenic centers on the β-lactam skeleton of ezetimibe were controlled by the syn-selective asymmetric Mannich reaction, followed by isomerization.

Original languageEnglish
Pages (from-to)30-32
Number of pages3
JournalChemistry Letters
Volume45
Issue number1
DOIs
Publication statusPublished - 2016

ASJC Scopus subject areas

  • Chemistry(all)

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