Food restriction in pregnant mice can induce changes in histone modifications and suppress gene expression in fetus.

Jafar Sharif; Michiyo Nakamura; Takuya Ito; Yoshitaka Kimura; Teruyuki Nagamune; Kohzoh Mitsuya; Kunihiro Okamura

doi:10.1093/nass/nrm063

Food restriction in pregnant mice can induce changes in histone modifications and suppress gene expression in fetus.

Jafar Sharif, Michiyo Nakamura, Takuya Ito, Yoshitaka Kimura, Teruyuki Nagamune, Kohzoh Mitsuya, Kunihiro Okamura

MED - Disability Science

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

Biological responses to environmental effects are mediated through epigenetic changes such as chemical modifications of the histone tails and DNA (5-cytosine) methylation. We report that dietary protein restriction in pregnant mice can alter histone modifications in the promoter region of the Igf2 gene and cause a two-fold repression in promoter specific Igf2 transcription in the liver of the fetus. Suppression of Igf2 is accompanied with low birth weight of the pups born to the protein-restricted dams. Our results provide new information about the epigenetic aspects of early life programming and will improve our understanding about the developmental origins of adult diseases.

Original language	English
Pages (from-to)	125-126
Number of pages	2
Journal	Nucleic acids symposium series (2004)
Issue number	51
DOIs	https://doi.org/10.1093/nass/nrm063
Publication status	Published - 2007

ASJC Scopus subject areas

Medicine(all)

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Food restriction in pregnant mice can induce changes in histone modifications and suppress gene expression in fetus. / Sharif, Jafar; Nakamura, Michiyo; Ito, Takuya; Kimura, Yoshitaka; Nagamune, Teruyuki; Mitsuya, Kohzoh; Okamura, Kunihiro.

In: Nucleic acids symposium series (2004), No. 51, 2007, p. 125-126.

Research output: Contribution to journal › Article › peer-review

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AU - Nagamune, Teruyuki

AU - Mitsuya, Kohzoh

AU - Okamura, Kunihiro

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AB - Biological responses to environmental effects are mediated through epigenetic changes such as chemical modifications of the histone tails and DNA (5-cytosine) methylation. We report that dietary protein restriction in pregnant mice can alter histone modifications in the promoter region of the Igf2 gene and cause a two-fold repression in promoter specific Igf2 transcription in the liver of the fetus. Suppression of Igf2 is accompanied with low birth weight of the pups born to the protein-restricted dams. Our results provide new information about the epigenetic aspects of early life programming and will improve our understanding about the developmental origins of adult diseases.

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Food restriction in pregnant mice can induce changes in histone modifications and suppress gene expression in fetus.

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