Abstract
Biological responses to environmental effects are mediated through epigenetic changes such as chemical modifications of the histone tails and DNA (5-cytosine) methylation. We report that dietary protein restriction in pregnant mice can alter histone modifications in the promoter region of the Igf2 gene and cause a two-fold repression in promoter specific Igf2 transcription in the liver of the fetus. Suppression of Igf2 is accompanied with low birth weight of the pups born to the protein-restricted dams. Our results provide new information about the epigenetic aspects of early life programming and will improve our understanding about the developmental origins of adult diseases.
Original language | English |
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Pages (from-to) | 125-126 |
Number of pages | 2 |
Journal | Nucleic acids symposium series (2004) |
Issue number | 51 |
DOIs | |
Publication status | Published - 2007 |
ASJC Scopus subject areas
- Medicine(all)