Food polyphenols targeting peptidyl prolyl cis/trans isomerase Pin1

Masafumi Hidaka, Keita Kosaka, Saori Tsushima, Chiyoko Uchida, Katsuhiko Takahashi, Noriko Takahashi, Masayoshi Tsubuki, Yukihiko Hara, Takafumi Uchida

    Research output: Contribution to journalArticlepeer-review

    9 Citations (Scopus)

    Abstract

    We searched for inhibitors against prolyl isomerase Pin1 in order to develop functional foods to prevent and cure various Pin1 related diseases such as cancer, diabetes, cardiovascular disease, Alzheimers's disease, and so on. We created a polyphenol library consisting of ingredients in healthy foods and beverages, since polyphenols like epigallocatechin gallate (EGCG) in green tea and 974B in brown algae had been identified as its Pin1 inhibitors. Several polyphenols such as EGCG derivatives, caffeic acid derivatives and tannic acid inhibited Pin1 activity. These results provide a first step in development of the functional foods and beverage targeting Pin1 and its related diseases.

    Original languageEnglish
    Pages (from-to)681-687
    Number of pages7
    JournalBiochemical and biophysical research communications
    Volume499
    Issue number3
    DOIs
    Publication statusPublished - 2018 May 15

    Keywords

    • Caffeic acid
    • EGCG
    • Food polyphenols
    • Pin1
    • Prolyl isomerase
    • Tannic acid

    ASJC Scopus subject areas

    • Biophysics
    • Biochemistry
    • Molecular Biology
    • Cell Biology

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