TY - JOUR
T1 - Foetal growth, birth transition, enteral nutrition and brain light scattering
AU - Iwata, Osuke
AU - Iwata, Sachiko
AU - Kurata, Tsuyoshi
AU - Tsuda, Kennosuke
AU - Kawase, Koya
AU - Kinoshita, Masahiro
AU - Lin, Yung Chieh
AU - Saikusa, Mamoru
AU - Araki, Yuko
AU - Takashima, Sachio
AU - Oda, Motoki
AU - Ohmae, Etsuko
AU - Saitoh, Shiji
N1 - Funding Information:
The authors thank the newborn infants and their families for their participation and cooperation with the study, and Ms. Chiho Yoshii and Chiaki Ueno for their consistent support. This work was supported by the Japan Society for the Promotion of Science (Grants-in-Aid for Scientific Research 20H00102, 16K09005, 18K07795 and 18K15722).
Publisher Copyright:
© 2021, The Author(s).
PY - 2021/12
Y1 - 2021/12
N2 - If the brain structure is assessed at neonatal intensive care units, covert clinical events related with subtle brain injury might be identified. The reduced scattering coefficient of near-infrared light (μS’) obtained using time-resolved near-infrared spectroscopy from the forehead of infants is associated with gestational age, body weight and Apgar scores, presumably reflecting subtle changes of the brain related to foetal growth and birth transition. One hundred twenty-eight preterm and term infants were studied to test whether μS’ obtained from the head at term-equivalent age is associated with foetal growth, birth transition and nutritional status after birth, which are key independent variables of developmental outcomes. As potential independent variables of μS’, birth weight, Apgar scores, age at full enteral feeding and post-conceptional age at the study were assessed to represent foetal growth, birth transition and nutritional status after birth. Subsequently, higher μS’ values were associated with higher Apgar scores (p = 0.003) and earlier establishment of enteral feeding (p < 0.001). The scattering property of near-infrared light within the neonatal brain might reflect changes associated with birth transition and nutritional status thereafter, which might be used as a non-invasive biomarker to identify covert independent variables of brain injury in preterm infants.
AB - If the brain structure is assessed at neonatal intensive care units, covert clinical events related with subtle brain injury might be identified. The reduced scattering coefficient of near-infrared light (μS’) obtained using time-resolved near-infrared spectroscopy from the forehead of infants is associated with gestational age, body weight and Apgar scores, presumably reflecting subtle changes of the brain related to foetal growth and birth transition. One hundred twenty-eight preterm and term infants were studied to test whether μS’ obtained from the head at term-equivalent age is associated with foetal growth, birth transition and nutritional status after birth, which are key independent variables of developmental outcomes. As potential independent variables of μS’, birth weight, Apgar scores, age at full enteral feeding and post-conceptional age at the study were assessed to represent foetal growth, birth transition and nutritional status after birth. Subsequently, higher μS’ values were associated with higher Apgar scores (p = 0.003) and earlier establishment of enteral feeding (p < 0.001). The scattering property of near-infrared light within the neonatal brain might reflect changes associated with birth transition and nutritional status thereafter, which might be used as a non-invasive biomarker to identify covert independent variables of brain injury in preterm infants.
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U2 - 10.1038/s41598-021-00624-9
DO - 10.1038/s41598-021-00624-9
M3 - Article
C2 - 34716370
AN - SCOPUS:85118443193
SN - 2045-2322
VL - 11
JO - Scientific Reports
JF - Scientific Reports
IS - 1
M1 - 21318
ER -