Focused ultrasonic device for sonodynamic therapy in the human body

A. Yasui, Yoichi Haga, J. J. Chen, H. Wada

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Citations (Scopus)

Abstract

Sonodynamic therapy is a new modality based on the synergistic effect of ultrasound and a chemical compound referred to as "sonosensitizer" for treatment of diseased sites such as cancer. However, by external ultrasound exposure, it is difficult to transmit ultrasound deep within the human body at adequate intensity because of transmission losses caused by the difference of specific acoustic impedance between media. Therefore, the aim of this study is to develop focused ultrasonic transducers using concave-shaped PZT for localized sonodynamic therapy in the human body. A concave-shaped PET was fabricated from a bulk PZT using a high-speed micro-milling machine, and then repolarized for the optimized polarization direction. The measurement result of the acoustic field using a PVDF hydrophone indicated that (he ultrasound emitted from the transducer was successfully focused in three-dimensions. At the focal point, the measured peak intensity would be sufficient for sonodynamic therapy.

Original languageEnglish
Title of host publication2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology
Pages154-157
Number of pages4
DOIs
Publication statusPublished - 2005 Dec 1
Event2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology - Oahu, HI, United States
Duration: 2005 May 122005 May 15

Publication series

Name2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology
Volume2005

Other

Other2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology
CountryUnited States
CityOahu, HI
Period05/5/1205/5/15

Keywords

  • Concave shape
  • Focused ultrasound
  • Milling machining
  • Repolarization
  • Sonodynamic therapy
  • Ultrasonic transducer

ASJC Scopus subject areas

  • Engineering(all)

Fingerprint Dive into the research topics of 'Focused ultrasonic device for sonodynamic therapy in the human body'. Together they form a unique fingerprint.

Cite this