Focal reduction in cardiac 123i-metaiodobenzylguanidine uptake in patients with anderson-fabry disease

Saori Yamamoto, Hideaki Suzuki, Koichiro Sugimura, Shunsuke Tatebe, Tatsuo Aoki, Masanobu Miura, Nobuhiro Yaoita, Haruka Sato, Katuya Kozu, Hideki Ota, Kentaro Takanami, Kei Takase, Hiroaki Shimokawa

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


Background: It remains to be elucidated whether cardiac sympathetic nervous activity is impaired in patients with Anderson-Fabry disease (AFD). Methods and Results: We performed 123I-meta-iodobenzylguanidine (MIBG) scintigraphy and gadolinium-enhanced cardiovascular magnetic resonance (CMR) in 5 AFD patients. MIBG uptake in the inferolateral wall, where wall thinning and delayed enhancement were noted on CMR, was significantly lower compared with the anteroseptal wall. The localized reduction in MIBG uptake was also noted in 2 patients with no obvious abnormal findings on CMR. Conclusions: Cardiac sympathetic nervous activity is impaired in AFD before development of structural myocardial abnormalities.

Original languageEnglish
Pages (from-to)2550-2551
Number of pages2
JournalCirculation Journal
Issue number12
Publication statusPublished - 2016


  • Anderson-fabry disease
  • Cardiomyopathy
  • Cardiovascular magnetic resonance
  • MIBG scintigraphy

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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