TY - JOUR
T1 - Focal Lamina Cribrosa Defect in Myopic Eyes With Nonprogressive Glaucomatous Visual Field Defect
AU - Sawada, Yu
AU - Araie, Makoto
AU - Kasuga, Hitomi
AU - Ishikawa, Makoto
AU - Iwata, Toyoto
AU - Murata, Katsuyuki
AU - Yoshitomi, Takeshi
N1 - Funding Information:
Funding/Support: This study is supported by a grant from the Japan Society for the Promotion of Science (JSPS) (number: 17k11417), Tokyo, Japan. Financial Disclosures: The following authors have no financial disclosures: Yu Sawada, Makoto Araie, Hitomi Kasuga, Makoto Ishikawa, Toyoto Iwata, Katsuyuki Murata, and Takeshi Yoshitomi. All authors attest that they meet the current ICMJE criteria for authorship.
Publisher Copyright:
© 2018 Elsevier Inc.
PY - 2018/6
Y1 - 2018/6
N2 - Purpose: To investigate focal lamina cribrosa (LC) defect that spatially correspond to the nonprogressive glaucomatous visual field defect (VFD) in myopic subjects. Design: Case-control study. Subjects: We included 159 myopic eyes with glaucomatous VFD under treatment and followed up for 7 years. Methods: Serial enhanced-depth imaging spectral-domain optical coherence tomography B-scans of the optic discs were acquired at the end of the follow-up and reviewed for the LC defect. Nonprogressive VFD was defined as having ≤1 progressing point of Humphrey visual field, with a slope calculated using pointwise linear regression worse than −1.0 dB/year at P <.01. Eyes were classified as having either progressive or nonprogressive VFD, and associating factors were evaluated. Results: Sixty-four subjects (40.3%) exhibited nonprogressive VFD with mean deviation change −0.06 ± 0.22 dB/year. Multivariate logistic regression analysis revealed that presence of LC defect was significantly associated with nonprogressive VFD (odds ratio, 3.96; P =.002). The location of LC defect corresponded spatially to the location of VFD. Nonprogressive eyes with LC defect exhibited lower baseline intraocular pressure (IOP) (16.6 mm Hg vs 21.0 mm Hg, P =.0030) and smaller percentage of IOP change (12.9% vs 30.5%, P <.0001) than those without LC defect, but greater myopic optic disc deformation (10.1 degrees vs 1.2 degrees in torsion angle, P <.0001). When the eyes with LC defect had higher baseline IOP, they exhibited progressive VFD. Conclusions: In myopic eyes, there are specific patters of LC defect that are suggested to be associated with nonprogressive glaucomatous VFD.
AB - Purpose: To investigate focal lamina cribrosa (LC) defect that spatially correspond to the nonprogressive glaucomatous visual field defect (VFD) in myopic subjects. Design: Case-control study. Subjects: We included 159 myopic eyes with glaucomatous VFD under treatment and followed up for 7 years. Methods: Serial enhanced-depth imaging spectral-domain optical coherence tomography B-scans of the optic discs were acquired at the end of the follow-up and reviewed for the LC defect. Nonprogressive VFD was defined as having ≤1 progressing point of Humphrey visual field, with a slope calculated using pointwise linear regression worse than −1.0 dB/year at P <.01. Eyes were classified as having either progressive or nonprogressive VFD, and associating factors were evaluated. Results: Sixty-four subjects (40.3%) exhibited nonprogressive VFD with mean deviation change −0.06 ± 0.22 dB/year. Multivariate logistic regression analysis revealed that presence of LC defect was significantly associated with nonprogressive VFD (odds ratio, 3.96; P =.002). The location of LC defect corresponded spatially to the location of VFD. Nonprogressive eyes with LC defect exhibited lower baseline intraocular pressure (IOP) (16.6 mm Hg vs 21.0 mm Hg, P =.0030) and smaller percentage of IOP change (12.9% vs 30.5%, P <.0001) than those without LC defect, but greater myopic optic disc deformation (10.1 degrees vs 1.2 degrees in torsion angle, P <.0001). When the eyes with LC defect had higher baseline IOP, they exhibited progressive VFD. Conclusions: In myopic eyes, there are specific patters of LC defect that are suggested to be associated with nonprogressive glaucomatous VFD.
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U2 - 10.1016/j.ajo.2018.03.018
DO - 10.1016/j.ajo.2018.03.018
M3 - Article
C2 - 29559412
AN - SCOPUS:85044850596
VL - 190
SP - 34
EP - 49
JO - American Journal of Ophthalmology
JF - American Journal of Ophthalmology
SN - 0002-9394
ER -