Fluvoxamine exerts anorexic effect in 5-HT2C receptor mutant mice with heterozygous mutation of -endorphin gene

Katsunori Nonogaki, Yukie Ohba, Mamoru Wakameda, Tomohiro Tamari

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Serotonin (5-hydroxytryptamine; 5-HT) 2C receptors and the downstream melanocortin pathway are suggested to mediate the anorexic effects of m-chlorophenylpiperazine (mCPP) and fenfluramine. We previously reported that fluvoxamine, a selective serotonin reuptake inhibitor, together with pharmacological inactivation of 5-HT2C receptors exert feeding suppression through activation of 5-HT1B receptors in mice. Here, we report that fluvoxamine exerted anorexic effects in 5-HT2C receptor mutant mice with heterozygous mutation of -endorphin gene (2CREnd mice), whereas fluvoxamine had no effect on food intake in age-matched wild-type mice and 5-HT2C receptor mutant mice, which are associated with decreases in hypothalamic proopiomelanocortin (POMC) expression. mCPP suppressed food intake in 5-HT2C receptor mutant mice, 2CREnd mice and age-matched wild-type mice. These results suggest that fluvoxamine-induced feeding suppression requires a perturbation of 5-HT2C receptor and -endorphin signalling plus functional hypothalamic POMC activity, whereas mCPP-induced feeding suppression does not always require functional 5-HT2C receptor, -endorphin, and POMC activity in mice.

Original languageEnglish
Pages (from-to)547-552
Number of pages6
JournalInternational Journal of Neuropsychopharmacology
Volume12
Issue number4
DOIs
Publication statusPublished - 2009 May

Keywords

  • 5-HT2C receptor
  • Fluvoxamine
  • Food intake
  • MCPP
  • Β-endorphin

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health
  • Pharmacology (medical)

Fingerprint Dive into the research topics of 'Fluvoxamine exerts anorexic effect in 5-HT2C receptor mutant mice with heterozygous mutation of -endorphin gene'. Together they form a unique fingerprint.

  • Cite this