Fluorine-18 radiopharmaceuticals beyond [18F]FDG for use in oncology and neurosciences

H. H. Coenen, P. H. Elsinga, R. Iwata, M. R. Kilbourn, M. R.A. Pillai, M. G.R. Rajan, H. N. Wagner, J. J. Zaknun

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    75 Citations (Scopus)


    Positron emission tomography (PET) is a rapidly expanding clinical modality worldwide thanks to the availability of compact medical cyclotrons and automated chemistry for the production of radiopharmaceuticals. There is an armamentarium of fluorine-18 (18F) tracers that can be used for PET studies in the fields of oncology and neurosciences. However, most of the 18F-tracers other than 2-deoxy-2-[18F]fluoro-D-glucose (FDG) are in less than optimum human use and there is considerable scope to bring potentially useful 18F-tracers to clinical investigation stage.The International Atomic Energy Agency (IAEA) convened a consultants' group meeting to review the current status of 18F-based radiotracers and to suggest means for accelerating their use for diagnostic applications. The consultants reviewed the developments including the synthetic approaches for the preparation of 18F-tracers for oncology and neurosciences. A selection of three groups of 18F-tracers that are useful either in oncology or in neurosciences was done based on well-defined criteria such as application, lack of toxicity, availability of precursors and ease of synthesis. Based on the recommendations of the consultants' group meeting, IAEA started a coordinated research project on "Development of 18F radiopharmaceuticals (beyond [18F]FDG) for use in oncology and neurosciences" in which 14 countries are participating in a 3-year collaborative program. The outcomes of the coordinated research project are expected to catalyze the wider application of several more 18F-radiopharmaceuticals beyond FDG for diagnostic applications in oncology and neurosciences.

    Original languageEnglish
    Pages (from-to)727-740
    Number of pages14
    JournalNuclear Medicine and Biology
    Issue number7
    Publication statusPublished - 2010 Oct 1

    ASJC Scopus subject areas

    • Molecular Medicine
    • Radiology Nuclear Medicine and imaging
    • Cancer Research

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    Coenen, H. H., Elsinga, P. H., Iwata, R., Kilbourn, M. R., Pillai, M. R. A., Rajan, M. G. R., Wagner, H. N., & Zaknun, J. J. (2010). Fluorine-18 radiopharmaceuticals beyond [18F]FDG for use in oncology and neurosciences. Nuclear Medicine and Biology, 37(7), 727-740. https://doi.org/10.1016/j.nucmedbio.2010.04.185