Fluorescent trimethyl-substituted naphthyridine as a ligand for C–C mismatch detection in CCG trinucleotide repeats

Yusuke Sato, Atsuko Honjo, Daisuke Ishikawa, Seiichi Nishizawa, Norio Teramae

Research output: Contribution to journalArticlepeer-review

30 Citations (Scopus)

Abstract

We report on the selective binding of 2-amino-5,6,7-trimethyl-1,8-naphthyridine (ATMND) to C–C mismatch present in the hairpin structures of (CCG)n trinucleotide repeats that are associated with neurological diseases; this binding is accompanied by significant fluorescence quenching of ATMND.

Original languageEnglish
Pages (from-to)5885-5887
Number of pages3
JournalChemical Communications
Volume47
Issue number20
DOIs
Publication statusPublished - 2011 May 3

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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