Fluorescent genipin cross-linked REDV-conjugated polymeric microbubbles for human vascular endothelial cell (HVEC) targeting

Zhe Liu; Changcan Shi; Yihong Li; Yuanhui Song; Qien Xu

doi:10.1039/c6ra00992a

Fluorescent genipin cross-linked REDV-conjugated polymeric microbubbles for human vascular endothelial cell (HVEC) targeting

Zhe Liu, Changcan Shi, Yihong Li, Yuanhui Song, Qien Xu

MED - United Centers for Advanced Research and Translational Medicine (ART)

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Polymeric microbubbles modified with chitosan and genipin were fabricated via emulsification, electrostatic interaction and cross-linking to afford intrinsic fluorescence. REDV peptides were conjugated to achieve HVEC active targeting. The degradation, cytotoxicity and targeting features made them potential candidates in early molecular diagnosis for cardiovascular diseases.

Original language	English
Pages (from-to)	32710-32714
Number of pages	5
Journal	RSC Advances
Volume	6
Issue number	39
DOIs	https://doi.org/10.1039/c6ra00992a
Publication status	Published - 2016

ASJC Scopus subject areas

Chemistry(all)
Chemical Engineering(all)

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10.1039/c6ra00992a

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title = "Fluorescent genipin cross-linked REDV-conjugated polymeric microbubbles for human vascular endothelial cell (HVEC) targeting",

abstract = "Polymeric microbubbles modified with chitosan and genipin were fabricated via emulsification, electrostatic interaction and cross-linking to afford intrinsic fluorescence. REDV peptides were conjugated to achieve HVEC active targeting. The degradation, cytotoxicity and targeting features made them potential candidates in early molecular diagnosis for cardiovascular diseases.",

author = "Zhe Liu and Changcan Shi and Yihong Li and Yuanhui Song and Qien Xu",

note = "Funding Information: The authors are grateful for the financial support by the National Natural Science Foundation of China (21575106), Scientific Research Foundation for Returned Scholars, Ministry of Education of China, Zhejiang Qianjiang Talents Program and Wenzhou Government's Start-up Fund (WIBEZD2014005-02). Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2016. Copyright: Copyright 2016 Elsevier B.V., All rights reserved.",

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language = "English",

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T1 - Fluorescent genipin cross-linked REDV-conjugated polymeric microbubbles for human vascular endothelial cell (HVEC) targeting

AU - Liu, Zhe

AU - Shi, Changcan

AU - Li, Yihong

AU - Song, Yuanhui

AU - Xu, Qien

N1 - Funding Information: The authors are grateful for the financial support by the National Natural Science Foundation of China (21575106), Scientific Research Foundation for Returned Scholars, Ministry of Education of China, Zhejiang Qianjiang Talents Program and Wenzhou Government's Start-up Fund (WIBEZD2014005-02). Publisher Copyright: © The Royal Society of Chemistry 2016. Copyright: Copyright 2016 Elsevier B.V., All rights reserved.

PY - 2016

Y1 - 2016

N2 - Polymeric microbubbles modified with chitosan and genipin were fabricated via emulsification, electrostatic interaction and cross-linking to afford intrinsic fluorescence. REDV peptides were conjugated to achieve HVEC active targeting. The degradation, cytotoxicity and targeting features made them potential candidates in early molecular diagnosis for cardiovascular diseases.

AB - Polymeric microbubbles modified with chitosan and genipin were fabricated via emulsification, electrostatic interaction and cross-linking to afford intrinsic fluorescence. REDV peptides were conjugated to achieve HVEC active targeting. The degradation, cytotoxicity and targeting features made them potential candidates in early molecular diagnosis for cardiovascular diseases.

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DO - 10.1039/c6ra00992a

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JO - RSC Advances

JF - RSC Advances

SN - 2046-2069

IS - 39

ER -

Fluorescent genipin cross-linked REDV-conjugated polymeric microbubbles for human vascular endothelial cell (HVEC) targeting

Abstract

ASJC Scopus subject areas

UN SDGs

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