Fluorescence-labeled neopeltolide derivatives for subcellular localization imaging

Shota Yanagi, Tomoya Sugai, Takuma Noguchi, Masato Kawakami, Makoto Sasaki, Shinsuke Niwa, Asako Sugimoto, Haruhiko Fuwa

Research output: Contribution to journalArticlepeer-review

Abstract

Design, synthesis and functional analysis of fluorescent derivatives of neopeltolide, an antiproliferative marine macrolide, are reported herein. Live cell imaging using the fluorescent derivatives showed rapid cellular uptake and localization within the endoplasmic reticulum as well as the mitochondria.

Original languageEnglish
Pages (from-to)6771-6776
Number of pages6
JournalOrganic and Biomolecular Chemistry
Volume17
Issue number28
DOIs
Publication statusPublished - 2019 Jan 1

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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