Fluorescence endoscopy using fiber speckle illumination

Shuhei Nakano, Takashi Katagiri, Yuji Matsuura

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

An endoscopic fluorescence imaging system based on fiber speckle illumination is proposed. In this system, a multimode fiber for transmission of excitation laser light and collection of fluorescence is inserted into a conventional flexible endoscope. Since the excitation laser light has random speckle structure, one can detect fluorescence signal corresponding to the irradiation pattern if the sample contains fluorophores. The irradiation pattern can be captured by the endoscope camera when the excitation wavelength is within the sensitivity range of the camera. By performing multiple measurements while changing the irradiation pattern, a fluorescence image is reconstructed by solving a norm minimization problem. The principle of our method was experimentally demonstrated. A 2048 pixels image of quantum dots coated on a frosted glass was successfully reconstructed by 32 measurements. We also confirmed that our method can be applied on biological tissues.

Original languageEnglish
Title of host publicationOptical Fibers and Sensors for Medical Diagnostics and Treatment Applications XVIII
EditorsIsrael Gannot, Israel Gannot
PublisherSPIE
ISBN (Electronic)9781510614611
DOIs
Publication statusPublished - 2018 Jan 1
EventOptical Fibers and Sensors for Medical Diagnostics and Treatment Applications XVIII 2018 - San Francisco, United States
Duration: 2018 Jan 272018 Jan 28

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume10488
ISSN (Print)1605-7422

Other

OtherOptical Fibers and Sensors for Medical Diagnostics and Treatment Applications XVIII 2018
CountryUnited States
CitySan Francisco
Period18/1/2718/1/28

Keywords

  • endoscope
  • fiber speckle
  • fluorescence imaging
  • multimode optical fiber
  • spectral imaging

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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