Fluctuations of the Sympathetic Nerve Discharges in Animals Without Natural Heartbeat

Tomoyuki Yambe, Shin–ichi Nitta, Shigeru Naganuma, Yoshito Kakinuma, Kenji Izutsu, Hiroshi Akiho, Tohru Naganuma, Yuhichi Kikuchi, Shin–ichi Kobayashi, Noboru Ohsawa, Shunsuke Nanka, Motonao Tanaka, Takeo Fukuju, Makoto Miura, Naoki Uchida, Naoshi Sato, Hitoshi Mohri, Satoshi Koide, Ken–ichi Abe, Hiroshi TakedaMakoto Yoshizawa

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Abstract: To assess the effect of artificial circulation on the circulatory regulatory system, rhythmical fluctuations in the cardiovascular system and autonomic nerve discharges were analyzed in animal experiments using adult mongrel dogs. Two pneumatically actuated ventricular assist devices were implanted as total biventricular bypass (BVB) under general anesthesia; then, the natural heart was electrically fibrillated to constitute the BVB part of the complete prosthetic circulation model. All hemodynamic data and sympathetic nerve discharges were recorded and calculated in the computer system by the use of spectral analyzing methods. In the power spectrum of the arterial blood pressure waveform during prosthetic circulation, the Mayer wave peak was significantly decreased though the respiratory wave peak was not signif icantly changed. However, the Mayer wave peak in sympathetic nerve discharges was significantly increased though the respiratory wave peak was not significantly changed. These results suggest that rhythmical fluctuations are a necessary response of the circulatory regulatory system including the autonomic nervous system. However, sympathetic nerve discharges respond to the artificial heart without rhythmical fluctuations.

Original languageEnglish
Pages (from-to)775-780
Number of pages6
JournalArtificial Organs
Volume18
Issue number10
DOIs
Publication statusPublished - 1994 Oct

Keywords

  • Artificial heart
  • Autonomic nervous system
  • Fluctuation
  • Mayer waves
  • Respiratory waves
  • Spectral analysis

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomaterials
  • Biomedical Engineering

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  • Cite this

    Yambe, T., Nitta, S., Naganuma, S., Kakinuma, Y., Izutsu, K., Akiho, H., Naganuma, T., Kikuchi, Y., Kobayashi, S., Ohsawa, N., Nanka, S., Tanaka, M., Fukuju, T., Miura, M., Uchida, N., Sato, N., Mohri, H., Koide, S., Abe, K., ... Yoshizawa, M. (1994). Fluctuations of the Sympathetic Nerve Discharges in Animals Without Natural Heartbeat. Artificial Organs, 18(10), 775-780. https://doi.org/10.1111/j.1525-1594.1994.tb03319.x