Fluctuation theorem applied to F1-ATPase

Kumiko Hayashi, Hiroshi Ueno, Ryota Iino, Hiroyuki Noji

Research output: Contribution to journalArticlepeer-review

115 Citations (Scopus)

Abstract

In recent years, theories of nonequilibrium statistical mechanics such as the fluctuation theorem (FT) and the Jarzynski equality have been experimentally applied to micro and nanosized systems. However, so far, these theories are seldom applied to autonomous systems such as motor proteins. In particular, representing the property of entropy production in a small system driven out of equilibrium, FT seems suitable to be applied to them. Hence, for the first time, we employed FT in the single molecule experiments of the motor protein F1-adenosine triphosphatase (F1), in which the rotor γ subunit rotates in the stator α3β3 ring upon adenosine triphosphate hydrolysis. We found that FT provided the better estimation of the rotary torque of F1 than the conventional method.

Original languageEnglish
Article number218103
JournalPhysical review letters
Volume104
Issue number21
DOIs
Publication statusPublished - 2010 May 28
Externally publishedYes

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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