Flow-mediated change in viscoelasticity of radial arterial wall measured by 22-MHz ultrasound

K. Ikeshita, Hideyuki Hasegawa, H. Kanai

Research output: Contribution to journalConference articlepeer-review

Abstract

The endothelial dysfunction is considered to be an initial step of atherosclerosis. Moreover, it was reported that the smooth muscle, which constructs the media of the artery, changes its characteristics due to early-stage atherosclerosis. Therefore, it is essential to develop a method for assessing the regional endothelial function and mechanical property of the arterial wall. There is an ultrasound-based conventional technique to measure the change in inner diameter of the brachial artery caused by flow-mediated dilation (FMD) after release of avascularization. In this study, the transient change in the mechanical property of the arterial wall was further revealed by measuring the stress-strain relationship during each heartbeat. For this measurement, the minute change in thickness (strain) of the radial artery was measured using the ultrasonic phased tracking method, together with the waveform of blood pressure (stress) which was continuously measured at the radial artery. From in vivo experiments, it was found the slope of the stress-strain hysteresis loop decreased due to FMD and the area, which depends on the ratio of elastic modulus and loss modulus (depends on viscosity), increased. These results show a potential of the proposed method for thorough analysis of the transient change in viscoelasticity due to FMD.

Original languageEnglish
Pages (from-to)5891-5896
Number of pages6
JournalProceedings - European Conference on Noise Control
Publication statusPublished - 2008 Dec 1
Event7th European Conference on Noise Control 2008, EURONOISE 2008 - Paris, France
Duration: 2008 Jun 292008 Jul 4

ASJC Scopus subject areas

  • Acoustics and Ultrasonics
  • Public Health, Environmental and Occupational Health
  • Building and Construction
  • Mechanical Engineering
  • Industrial and Manufacturing Engineering
  • Automotive Engineering
  • Aerospace Engineering

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