Fish peptides appear to have essential roles in the survival of the fish. Melanin-concentrating hormones (MCH), urotensins, and stanniocalcin (STC) were originally discovered in fish, from the pituitary, urophysis, and corpuscles of Stannius, respectively. The color change regulated by MCH and a-melanocyte-stimulating hormone (aMSH) plays a critical role in protecting fish from their enemies. Osmoregulation controlled by urotensins is also essential for the fish living in both freshwater and seawater. The protection against calcium concentration change in water by STCs must be essential for the fish, which lives in water with a broad range of calcium concentrations. It may not be surprising that these fish peptides also have important roles in human physiology such as in circulation, appetite control, and cell differentiation and in the pathophysiology of human diseases, such as the metabolic syndrome, cardiovascular disease, and cancers.
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)