TY - JOUR
T1 - Fish intake and risk of mortality due to aortic dissection and aneurysm
T2 - A pooled analysis of the Japan cohort consortium
AU - Research Group for the Development and Evaluation of Cancer Prevention Strategies in Japan
AU - Yamagishi, Kazumasa
AU - Iso, Hiroyasu
AU - Shimazu, Taichi
AU - Tamakoshi, Akiko
AU - Sawada, Norie
AU - Matsuo, Keitaro
AU - Ito, Hidemi
AU - Wakai, Kenji
AU - Nakayama, Tomio
AU - Kitamura, Yuri
AU - Sado, Junya
AU - Tsuji, Ichiro
AU - Sugawara, Yumi
AU - Mizoue, Tetsuya
AU - Inoue, Manami
AU - Nagata, Chisato
AU - Sadakane, Atsuko
AU - Tanaka, Keitaro
AU - Tsugane, Shoichiro
AU - Sasazuki, Shizuka
N1 - Funding Information:
This work was supported by the National Cancer Center Research and Development Fund [grant numbers 27-A-4 and 30-A-15], National Cancer Center, Tokyo.
Funding Information:
This work was supported by the National Cancer Center Research and Development Fund [grant numbers 27-A-4 and 30-A-15 ], National Cancer Center , Tokyo.
Publisher Copyright:
© 2018 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism
Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.
PY - 2019/8
Y1 - 2019/8
N2 - Background & aims: Many studies have suggested that fish intake is associated with protection from risk of atherosclerotic diseases; however, this association with aortic diseases has not been elucidated worldwide. We hypothesized that fish intake is inversely associated with mortality from aortic diseases (aortic dissection and aneurysm). Methods: The study was conducted as a pooled analysis of original data from a maximum of 8 cohort studies, comprising a total of 366,048 community-based men and women who had no history of cardiovascular disease or cancer. In each cohort, we used Cox proportional hazards regression to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for mortality from aortic dissection, aneurysm and total aortic disease according to the frequency of fish intake and estimated summary HRs derived from each study. Results: Nonlinear inverse associations were found between fish intake and total aortic disease. Compared with persons who ate fish 1–2 times/week, persons who seldom ate fish had higher mortality from total aortic disease (multivariable-adjusted pooled HR = 1.93; 95% CI, 1.13–3.31). Higher mortality was not seen in those who ate fish 1–2 times/month. A similar pattern was observed for aortic dissection. Regarding aortic aneurysm, both persons who seldom ate fish and those who ate fish 1–2 times/month had higher mortality (HR = 1.99; 95% CI, 0.90–4.40 and HR = 1.86; 95% CI, 0.87–3.98, respectively). Conclusions: Persons who seldom ate fish had higher mortality from aortic dissection, aneurysm, and total aortic diseases.
AB - Background & aims: Many studies have suggested that fish intake is associated with protection from risk of atherosclerotic diseases; however, this association with aortic diseases has not been elucidated worldwide. We hypothesized that fish intake is inversely associated with mortality from aortic diseases (aortic dissection and aneurysm). Methods: The study was conducted as a pooled analysis of original data from a maximum of 8 cohort studies, comprising a total of 366,048 community-based men and women who had no history of cardiovascular disease or cancer. In each cohort, we used Cox proportional hazards regression to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for mortality from aortic dissection, aneurysm and total aortic disease according to the frequency of fish intake and estimated summary HRs derived from each study. Results: Nonlinear inverse associations were found between fish intake and total aortic disease. Compared with persons who ate fish 1–2 times/week, persons who seldom ate fish had higher mortality from total aortic disease (multivariable-adjusted pooled HR = 1.93; 95% CI, 1.13–3.31). Higher mortality was not seen in those who ate fish 1–2 times/month. A similar pattern was observed for aortic dissection. Regarding aortic aneurysm, both persons who seldom ate fish and those who ate fish 1–2 times/month had higher mortality (HR = 1.99; 95% CI, 0.90–4.40 and HR = 1.86; 95% CI, 0.87–3.98, respectively). Conclusions: Persons who seldom ate fish had higher mortality from aortic dissection, aneurysm, and total aortic diseases.
KW - Diet
KW - Epidemiology
KW - Fatty acids
KW - Meta-analysis
KW - Prospective cohort study
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U2 - 10.1016/j.clnu.2018.08.007
DO - 10.1016/j.clnu.2018.08.007
M3 - Article
C2 - 30172657
AN - SCOPUS:85052755942
VL - 38
SP - 1678
EP - 1683
JO - Clinical Nutrition
JF - Clinical Nutrition
SN - 0261-5614
IS - 4
ER -