TY - JOUR
T1 - Fish consumption and risk of incident dementia in elderly Japanese
T2 - The Ohsaki cohort 2006 study
AU - Tsurumaki, Nozomu
AU - Zhang, Shu
AU - Tomata, Yasutake
AU - Abe, Saho
AU - Sugawara, Yumi
AU - Matsuyama, Sanae
AU - Tsuji, Ichiro
N1 - Funding Information:
This research was funded by the NARO Bio-oriented Technology Research Advancement Institution (advanced integration research for agriculture and interdisciplinary fields). None of the funding organisations or sponsors was involved in the study design; in the collection, analysis or interpretation of data; in the writing of the report or in the decision to submit the article for publication.
Publisher Copyright:
© The Authors 2019.
PY - 2019/11/28
Y1 - 2019/11/28
N2 - Fish harbour many types of nutrients that are beneficial for preventing cognitive decline. Therefore, habitual fish intake might contribute to a lower risk of incident dementia. However, few prospective cohort studies have investigated fish consumption in relation to incident dementia, and their findings have been inconsistent. To investigate the association between fish consumption and the risk of incident dementia, we collected data on the consumption of fish and other foods using an FFQ in a baseline survey of individuals aged ≥65 years living in Ohsaki City, Japan. After 5·7 years of follow-up, the incidence of dementia was 1118 (8·5 %) among 13 102 participants. We then used a multivariate-adjusted Cox model to estimate hazard ratios (HR) and 95 % CI. Compared with subjects with the lowest fish intake (Q1), the multivariate HR were 0·90 (95 % CI 0·74, 1·11) for Q2, 0·85 (95 % CI 0·73, 0·99) for Q3 and 0·84 (95 % CI 0·71, 0·997) for Q4 (Ptrend = 0·029). Such associations were also observed even after excluding participants who were diagnosed with dementia in the first 2 years of follow-up and those who had poorer cognitive function at baseline. In conclusion, an association was observed between higher fish consumption and a lower risk of incident dementia among healthy elderly people without disability. These findings suggest that habitual fish intake may be beneficial for the prevention of dementia.
AB - Fish harbour many types of nutrients that are beneficial for preventing cognitive decline. Therefore, habitual fish intake might contribute to a lower risk of incident dementia. However, few prospective cohort studies have investigated fish consumption in relation to incident dementia, and their findings have been inconsistent. To investigate the association between fish consumption and the risk of incident dementia, we collected data on the consumption of fish and other foods using an FFQ in a baseline survey of individuals aged ≥65 years living in Ohsaki City, Japan. After 5·7 years of follow-up, the incidence of dementia was 1118 (8·5 %) among 13 102 participants. We then used a multivariate-adjusted Cox model to estimate hazard ratios (HR) and 95 % CI. Compared with subjects with the lowest fish intake (Q1), the multivariate HR were 0·90 (95 % CI 0·74, 1·11) for Q2, 0·85 (95 % CI 0·73, 0·99) for Q3 and 0·84 (95 % CI 0·71, 0·997) for Q4 (Ptrend = 0·029). Such associations were also observed even after excluding participants who were diagnosed with dementia in the first 2 years of follow-up and those who had poorer cognitive function at baseline. In conclusion, an association was observed between higher fish consumption and a lower risk of incident dementia among healthy elderly people without disability. These findings suggest that habitual fish intake may be beneficial for the prevention of dementia.
KW - Dementia
KW - Elderly people
KW - Fish
KW - Japan
KW - Prospective cohort studies
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U2 - 10.1017/S0007114519002265
DO - 10.1017/S0007114519002265
M3 - Article
C2 - 31477191
AN - SCOPUS:85071950252
VL - 122
SP - 1182
EP - 1191
JO - British Journal of Nutrition
JF - British Journal of Nutrition
SN - 0007-1145
IS - 10
ER -